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Antioxidants & Coenzyme Q10 in Cancer Prevention & Treatment.

Dr. Nancy Scanlan presented this at 1999 AHVMA annual conference. There are many researches done on antioxidants, which show effectiveness in prevention and treatment of cancer.

Antioxidants protect against chemotherapy toxicity and local toxic effects of tumors or surrounding tissues. Antioxidants act to inhibit or reverse oxidation. Free radicals are potentially carcinogenic, and are created by healthy cell metabolism, diseased cells, carcinogen, treatment with chemotherapy, treatment with radiation, cancer.  Action of free radicals can damage DNA, cause mutations, damage proteins, damage lipids, damage carbohydrates, alter function of proteins, lipids, carbohydrates, and create more free radicals.

One very interesting thing about cancer cells are that they lose apoptosis (programmed cell death) ability. Vitamin E sccunate inhibit growth and induce apoptosis ability of human breast cancer cell and colorectal cancer cell. Retinoids induced apoptosis in canine osteosarcoma, sulfur containing antioxidant works for cancer cell lines, flavopiridol for leukemia but not for prostate cancer.

Studies show that antioxidant inhibit cell proliferation. Vitamin E showed this ability to breast cancer cells. Gentistein did this for normal and tumor cells. Silymarin modulates cell cycle regulatory proteins, inhibits growth of prostate cancer.  Vitamin A is useful after the surgery to stop cancer cells from spreading. Many people are worry about toxicity on vitamin A.  For human, acute toxicity is 2,000,000 iu. Chronic toxicity is 500,000 iu daily for 2 months, or 50,000 iu daily for 18 months. For cat and small dog, 100,000 iu daily for 6 months, and 10,000 iu once or twice a week. For 35 - 60 lb dog, 25,000 iu a week. Vitamin E supplement will counteract the toxicity of vitamin A.

Study showed decreased activity of certain oncogenies when SOD was increased. Vitamin C inhibits growth of stomach cancer, Coenzyme Q10 is involved in DNA synthesis and decreases mutations.

Word about Beta carotene. Beta Carotene is just one of the over 500 carotenoids. Beta carotene showed promising result on oral leukoplakias, skin cancer, sarcomas, but there was an increased risk for thyroid cancer in an Italians who have the highest consumption of beta carotene. It actually increases the chance of getting two types of king cancer. Dr. Scanlan do not recommend giving only beta carotene.

Vitamin C has stronger antioxidant effect than vitamin A, E, or beta carotene. It can prevent the start of lipid damage. Diets high in vitamin C decrease cancer, especially of the esophagus and stomach, uterine cervical dysplasia, breast, larynx, oral cavity, pancreas, rectum and cervix. It is good for almost every cancer except for nonlymphocytic leukemia. However, there is a study about ill effect of vitamin C. Rats were fed high dose of vitamin C, second generation rats developed renal calcification and bladder carcinoma. If your animals do not have cancer, give very low dosage. Do not use time release type. This type is made for human intestine. Dogs or cats with short intestine will not be able to get anything out of it. Vitamin C will counteract vitamin E's side effect to prolong blood clotting time.

Bioflavonoids are the active red, yellow and blue pigmentations that accompany vitamin C in plants. There are thousands of bioflavonoids. Pycnogenol, cranberry, citrus, grape seed, genistein to name a few. These have different bioflavonoids and it is better to use several kinds rather than just one type.

Selenium works with vitamin E. It is more effective as cancer prevention than as cancer treatment. Vitamin E, given solely, actually change to a pro-oxidant rather than doing a job as antioxidant. Vitamin E also worked better with vitamin C. In mast cell tumors, a combination os quercitin, vitamin C and bioflavonoids can stabilize mast cell membranes.

As you can see, difference antioxidants are good for difference types of cancer. It is advisable to give mixed antioxidant, instead of just one kind, to prevent and treat cancer. Supplements should be in capsule form rather than tablet form.

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Benefits of Coenzyme Q10 | Treatment of Heart Disease with Coenzyme Q10 | Coenzyme Q10 & Parkinson's Disease
Coenzyme Q10 & Huntington's Disease | Coenzyme Q10 Protects Brain Cells | Antioxidants & Coenzyme Q10 in Cancer Prevention and Treatment
Neuroprotective Effects of Coenzyme Q10 | Coenzyme Q10 Protects Against Excitotoxicity | CoQ10 in Treatment of Mitochondrial & Neuromuscular Diseases
Side Effects of Coenzyme Q10 | What is Coenzyme Q10? | Discovery of Coenzyme Q10 | Future of Coenzyme Q10

 


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